The first precedent of formal bilateral relations took place in 1836, when the United States issued an exequatur to John Darby, as Consul General of Uruguay in New York. In 1867, diplomatic relations were established when Minister Resident Alexander Asboth presented his credentials to the Government of Uruguay.

Uruguay and the United States enjoy a strong bilateral relationship, which is demonstrated by the depth and length of matters of great importance to both. The relations encompass shared fields of endeavor, including trade and investment, promotion of democratic values and Human Rights, regional defense and security cooperation, cultural exchanges, education programs, scientific research, and tourism.

Underlying this rich bilateral agenda, several common values and principles have guided successive administrations, inter alia, a strong commitment to democracy, the rule of law, and the multilateral system, the advancement of labor rights and transparent economic policies, and the peaceful resolution of disputes between nations as one of the cornerstones of international law.

The United States and Uruguay are key partners, united by solid historical, cultural, political, and economic ties that date back more than two hundred years. The 21st century has opened many opportunities and challenges to keep strengthening this long-standing strategic partnership.